Issue 29, 2011
From the journal:

Chemical Communications

Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification†

Hong Zhou,a   Jing Liu,a   Jing-Juan Xu*a  and  Hong-Yuan Chena  

* Corresponding authors

a Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P.R. China
E-mail: xujj@nju.edu.cn
Fax: +86-25-83597924
Tel: +86-25-83597924

Abstract

We report here an ultrasensitive DNA detection approach which combines Au NPs enhanced electrochemiluminescence (ECL) of the CdS nanocrystal (NC) film with isothermal circular amplification reaction of polymerase and nicking endonuclease (NEase). By the double-signal amplification, this approach could sensitively respond down to 5 aM DNA.

Graphical abstract: Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

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Article information

DOI
https://doi.org/10.1039/C1CC12413G
Article type
Communication
Submitted
26 Apr 2011
Accepted
07 Jun 2011
First published
21 Jun 2011

Chem. Commun., 2011,47, 8358-8360

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Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

H. Zhou, J. Liu, J. Xu and H. Chen, Chem. Commun., 2011, 47, 8358 DOI: 10.1039/C1CC12413G

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