Issue 27, 2011
From the journal:

Chemical Communications

Total synthesis of (±)-chamobtusin A†‡

Hikaru Suzukia  and  Sakae Aoyagi*a  

* Corresponding authors

a School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
E-mail: aoyagis@toyaku.ac.jp
Fax: +81 42 676 4480
Tel: +81 42 676 4479

Abstract

The total synthesis of chamobtusin A, the first diterpenoid alkaloid isolated from the whole Pinales, is described. Key features of the synthesis include a stereoselective intramolecular Michael addition to install a key stereocenter and an oxidative manipulation to prepare a 2H-pyrrole ring.

Graphical abstract: Total synthesis of (±)-chamobtusin A

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Article information

DOI
https://doi.org/10.1039/C1CC12267C
Article type
Communication
Submitted
19 Apr 2011
Accepted
18 May 2011
First published
01 Jun 2011

Chem. Commun., 2011,47, 7878-7879

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Total synthesis of (±)-chamobtusin A

H. Suzuki and S. Aoyagi, Chem. Commun., 2011, 47, 7878 DOI: 10.1039/C1CC12267C

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