Issue 33, 2011
From the journal:

Chemical Communications

Creation of novel signalling modulators from existing cytokine using scanning motif-programming†

Tatsuya Murakami,‡ab   Kenji Kashiwagia  and  Kiyotaka Shiba*a  

* Corresponding authors

a Division of Protein Engineering, Cancer Institute, Japanese Foundation for Cancer Research, Koto, Tokyo 135-8550, Japan
E-mail: kshiba@jfcr.or.jp
Fax: +81-3-3570-0461
Tel: +81-3-3570-0489

b PRESTO, JST, 4-1-8 Honcho, Kawaguchi, Japan
E-mail: murakami@icems.kyoto-u.ac.jp
Fax: +81-75-753-9820
Tel: +81-75-753-9859

Abstract

We created two artificial modulating proteins for bone morphogenetic protein (BMP)-signalling, tmw57 and tmw61, starting from partial sequences of human BMP-2 (hBMP-2). The proteins were able to boost the hBMP-4 activities, BMP responsive element-driven transcription and an osteoblastic differentiation marker induction.

Graphical abstract: Creation of novel signalling modulators from existing cytokine using scanning motif-programming

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Article information

DOI
https://doi.org/10.1039/C1CC12214B
Article type
Communication
Submitted
18 Apr 2011
Accepted
04 Jul 2011
First published
18 Jul 2011

Chem. Commun., 2011,47, 9357-9359

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Creation of novel signalling modulators from existing cytokine using scanning motif-programming

T. Murakami, K. Kashiwagi and K. Shiba, Chem. Commun., 2011, 47, 9357 DOI: 10.1039/C1CC12214B

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