Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

David J. Berry; Yongmin Ma; James R. Ballinger; Richard Tavaré; Alexander Koers; Kavitha Sunassee; Tao Zhou; Saima Nawaz; Gregory E. D. Mullen; Robert C. Hider; Philip J. Blower

doi:10.1039/C1CC12123E

Efficient bifunctional gallium-68chelators for positron emission tomography: tris(hydroxypyridinone) ligands†

David J. Berry,^a Yongmin Ma,^ab James R. Ballinger,^a Richard Tavaré,^a Alexander Koers,^a Kavitha Sunassee,^a Tao Zhou,^b Saima Nawaz,^a Gregory E. D. Mullen,^a Robert C. Hider^b and Philip J. Blower*^a

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^a King's College London, Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St Thomas’ Hospital, London, UK
E-mail: Philip.Blower@kcl.ac.uk

^b King's College London, Institute of Pharmaceutical Science, Franklin Wilkins Building, London, UK

Abstract

A new tripodal tris(hydroxypyridinone) bifunctional chelator for gallium allows easy production of ⁶⁸Ga-labelled proteins rapidly under mild conditions in high yields at exceptionally high specific activity and low concentration.

Chemical Communications

Efficient bifunctional gallium-68chelators for positron emission tomography: tris(hydroxypyridinone) ligands†

Abstract

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Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

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