Issue 20, 2011
From the journal:

Chemical Communications

Exerting control over the acyloin reaction†

Timothy J. Donohoe,*a   Ali Jahanshahi,a   Michael J. Tucker,a   Farrah L. Bhatti,a   Ishmael A. Roslan,a   Mikhail Kabeshova  and  Gail Wrigleyb  

* Corresponding authors

a Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, UK
E-mail: timothy.donohoe@chem.ox.ac.uk
Tel: +44 (0)1865 275649

b Astrazeneca, CIRA Discovery Chemistry, Mereside, Alderley Park, Macclesfield, UK

Abstract

A synthetic method for conducting the acyloin reaction using electron transfer in solution is reported. By linking two estersvia their oxygen atoms, it was possible to perform crossed acyloin reactions between two different ester functionalities and display a high degree of preference for an intramolecular coupling process.

Graphical abstract: Exerting control over the acyloin reaction

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Article information

DOI
https://doi.org/10.1039/C1CC11654A
Article type
Communication
Submitted
22 Mar 2011
Accepted
06 Apr 2011
First published
18 Apr 2011

Chem. Commun., 2011,47, 5849-5851

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Exerting control over the acyloin reaction

T. J. Donohoe, A. Jahanshahi, M. J. Tucker, F. L. Bhatti, I. A. Roslan, M. Kabeshov and G. Wrigley, Chem. Commun., 2011, 47, 5849 DOI: 10.1039/C1CC11654A

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