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Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (∼150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler.

Graphical abstract: Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

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