Issue 19, 2011
From the journal:

Chemical Communications

What is the initiation step of the Grubbs-Hoveyda olefinmetathesiscatalyst?†

Ian W. Ashworth,a   Ian H. Hillier,*b   David J. Nelson,c   Jonathan M. Percy*c  and  Mark A. Vincentb  

* Corresponding authors

a AstraZeneca Global Research and Development, Silk Road Business Park, Charter Way, Macclesfield, UK

b School of Chemistry, University of Manchester, Oxford Road, Manchester, UK
E-mail: ian.hillier@manchester.ac.uk
Fax: +44 161 275 4734
Tel: +44 161 275 4687

c WestCHEM Department of Pure and Applied Chemistry, Thomas Graham Building, 295 Cathedral Street, Glasgow, UK
E-mail: jonathan.percy@strath.ac.uk
Fax: +44 141 548 4822
Tel: +44 141 548 4398

Abstract

Density function theory calculations reveal that the Grubbs-Hoveyda olefinmetathesis pre-catalyst is activated by the formation of a complex in which the incoming alkene substrate and outgoing alkoxy ligand are both clearly associated with the ruthenium centre. The computed energies for reaction are in good agreement with the experimental values, reported here.

Graphical abstract: What is the initiation step of the Grubbs-Hoveyda olefin metathesis catalyst?

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Article information

DOI
https://doi.org/10.1039/C1CC11230A
Article type
Communication
Submitted
01 Mar 2011
Accepted
28 Mar 2011
First published
11 Apr 2011

Chem. Commun., 2011,47, 5428-5430

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What is the initiation step of the Grubbs-Hoveyda olefinmetathesiscatalyst?

I. W. Ashworth, I. H. Hillier, D. J. Nelson, J. M. Percy and M. A. Vincent, Chem. Commun., 2011, 47, 5428 DOI: 10.1039/C1CC11230A

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