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Issue 26, 2011
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Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen

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Abstract

Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs; ‘profens’), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.

Graphical abstract: Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen

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Publication details

The article was received on 09 Feb 2011, accepted on 26 Apr 2011 and first published on 26 May 2011


Article type: Communication
DOI: 10.1039/C1CC10763A
Citation: Chem. Commun., 2011,47, 7332-7334

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    Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen

    T. J. Woodman, P. J. Wood, A. S. Thompson, T. J. Hutchings, G. R. Steel, P. Jiao, M. D. Threadgill and M. D. Lloyd, Chem. Commun., 2011, 47, 7332
    DOI: 10.1039/C1CC10763A

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