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Issue 16, 2011
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Increasing synthetic efficiency via direct C–H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin

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Abstract

A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C–H functionalization reactions, formally activating three C–H bonds.

Graphical abstract: Increasing synthetic efficiency via direct C–H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin

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Publication details

The article was received on 08 Feb 2011, accepted on 25 Feb 2011 and first published on 21 Mar 2011


Article type: Communication
DOI: 10.1039/C1CC10755K
Chem. Commun., 2011,47, 4679-4681

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    Increasing synthetic efficiency via direct C–H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin

    S. Potavathri, A. Kantak and B. DeBoef, Chem. Commun., 2011, 47, 4679
    DOI: 10.1039/C1CC10755K

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