Issue 16, 2011
From the journal:

Chemical Communications

Increasing synthetic efficiency via direct C–H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin†‡

Shathaverdhan Potavathri,a   Abhishek Kantaka  and  Brenton DeBoef*a  

* Corresponding authors

a Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, USA
E-mail: bdeboef@chm.uri.edu

Abstract

A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C–H functionalization reactions, formally activating three C–H bonds.

Graphical abstract: Increasing synthetic efficiency via direct C–H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin

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Article information

DOI
https://doi.org/10.1039/C1CC10755K
Article type
Communication
Submitted
08 Feb 2011
Accepted
25 Feb 2011
First published
21 Mar 2011

Chem. Commun., 2011,47, 4679-4681

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Increasing synthetic efficiency via direct C–H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin

S. Potavathri, A. Kantak and B. DeBoef, Chem. Commun., 2011, 47, 4679 DOI: 10.1039/C1CC10755K

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