Issue 17, 2011
From the journal:

Chemical Communications

Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide–alkyne cycloaddition reaction†

Kazumitsu Onizuka,ab   Atsushi Shibata,ab   Yosuke Taniguchiab  and  Shigeki Sasaki*ab  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
E-mail: saski@phar.kyushu-u.ac.jp
Fax: +81-92-642-6615
Tel: +81-92-642-6615

b CREST, Japan Science and Technology Agency, 4-1-8 Motomachi, Kawaguchi, Saitama 332-0012, Japan

Abstract

The internal modification of RNA has been successfully achieved by the functionality transfer reaction (FTR) and following click chemistry with diverse azide compounds. The benefits of the FTR have been demonstrated by its specificity, rapidity, broad applicability, and procedure simplicity.

Graphical abstract: Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide–alkyne cycloaddition reaction

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Article information

DOI
https://doi.org/10.1039/C1CC10582E
Article type
Communication
Submitted
29 Jan 2011
Accepted
04 Mar 2011
First published
23 Mar 2011

Chem. Commun., 2011,47, 5004-5006

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Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide–alkyne cycloaddition reaction

K. Onizuka, A. Shibata, Y. Taniguchi and S. Sasaki, Chem. Commun., 2011, 47, 5004 DOI: 10.1039/C1CC10582E

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