Issue 16, 2011
From the journal:

Chemical Communications

Synthesis of organic–inorganic hybrid bicelles–lipid bilayer nanodiscs encompassed by siloxane surfaces†

Kazuma Yasuhara,*a   Shohei Miki,a   Hajime Nakazono,a   Akio Ohtab  and  Jun-ichi Kikuchi*a  

* Corresponding authors

a Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 6300192, Japan
E-mail: yasuhara@ms.naist.jp, jkikuchi@ms.naist.jp
Fax: +81-743-72-6099
Tel: +81-743-2-6093

b School of Chemistry, College of Science and Engineering, Kanazawa University, Kakuma, Kanazawa, Ishikawa 9201192, Japan

Abstract

Well-defined hybrid nanodiscs were produced by employing bicelle formation of a binary lipid mixture in water. The resulting nanoparticles have a lipid bilayer coated with ceramic layers, which are formed by the sol–gel reaction among the alkoxysilyl headgroups of the hybrid lipid. The hybrid bicelles displayed significant morphological stability against dry environments and surfactant addition, in stark contrast to conventional phospholipid bicelles.

Graphical abstract: Synthesis of organic–inorganic hybrid bicelles–lipid bilayer nanodiscs encompassed by siloxane surfaces

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Article information

DOI
https://doi.org/10.1039/C1CC10254K
Article type
Communication
Submitted
14 Jan 2011
Accepted
28 Feb 2011
First published
15 Mar 2011

Chem. Commun., 2011,47, 4691-4693

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Synthesis of organic–inorganic hybrid bicelles–lipid bilayer nanodiscs encompassed by siloxane surfaces

K. Yasuhara, S. Miki, H. Nakazono, A. Ohta and J. Kikuchi, Chem. Commun., 2011, 47, 4691 DOI: 10.1039/C1CC10254K

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