Issue 13, 2011

A cascade Heck–Aldol–Heck reaction by a combination of transition-metal catalysis and aminocatalysis

Abstract

An unprecedented cascade Heck–Aldol–Heck reaction was developed to form two C–C single bonds and one C[double bond, length as m-dash]C double bond in one process by a combination of palladium(0) catalysis and aminocatalysis. Various aryl iodides could perform the cascade reaction with readily available propenol and formaldehyde to afford novel (E)-trisubstituted alkenes in 66–81% yields.

Graphical abstract: A cascade Heck–Aldol–Heck reaction by a combination of transition-metal catalysis and aminocatalysis

Supplementary files

Article information

Article type
Communication
Submitted
09 Jan 2011
Accepted
31 Jan 2011
First published
17 Feb 2011

Chem. Commun., 2011,47, 3995-3997

A cascade Heck–Aldol–Heck reaction by a combination of transition-metal catalysis and aminocatalysis

C. Guo, Y. Du and Z. Huang, Chem. Commun., 2011, 47, 3995 DOI: 10.1039/C1CC10152H

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