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Issue 11, 2011
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A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

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Abstract

A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.

Graphical abstract: A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

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Publication details

The article was received on 07 Jan 2011, accepted on 27 Jan 2011 and first published on 11 Feb 2011


Article type: Communication
DOI: 10.1039/C1CC10141B
Chem. Commun., 2011,47, 3096-3098

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    A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

    F. L. Thorp-Greenwood, V. Fernández-Moreira, C. O. Millet, C. F. Williams, J. Cable, J. B. Court, A. J. Hayes, D. Lloyd and M. P. Coogan, Chem. Commun., 2011, 47, 3096
    DOI: 10.1039/C1CC10141B

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