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Issue 18, 2011
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Inhibitors of an essential mycobacterialcell walllipase (Rv3802c) as tuberculosis drug leads

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Abstract

The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.

Graphical abstract: Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

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Article information


Submitted
16 Dec 2010
Accepted
17 Feb 2011
First published
07 Mar 2011

Chem. Commun., 2011,47, 5166-5168
Article type
Communication

Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

N. P. West, K. M. Cergol, M. Xue, E. J. Randall, W. J. Britton and R. J. Payne, Chem. Commun., 2011, 47, 5166
DOI: 10.1039/C0CC05635A

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