Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 9, 2011
Previous Article Next Article

Catalytic asymmetric conjugate addition of Grignard reagents to coumarins—synthesis of versatile chiral building blocks

Author affiliations

Abstract

A new protocol for the Cu-catalysed asymmetric conjugate addition of Grignard reagents to coumarins has been developed. The corresponding products are formed in high yields and enantioselectivities. Through a sequential protocol involving conjugate addition followed by nucleophilic ring opening of the chiral enolate, chiral esters and amides are readily accessible.

Graphical abstract: Catalytic asymmetric conjugate addition of Grignard reagents to coumarins—synthesis of versatile chiral building blocks

Back to tab navigation

Supplementary files

Article information


Submitted
24 Nov 2010
Accepted
10 Jan 2011
First published
31 Jan 2011

Chem. Commun., 2011,47, 2679-2681
Article type
Communication

Catalytic asymmetric conjugate addition of Grignard reagents to coumarins—synthesis of versatile chiral building blocks

J. F. Teichert and B. L. Feringa, Chem. Commun., 2011, 47, 2679
DOI: 10.1039/C0CC05160H

Social activity

Search articles by author

Spotlight

Advertisements