Issue 7, 2011
From the journal:

Chemical Communications

Synthesis and characterization of small circular double-stranded RNAs†

Naoko Abe,a   Hiroshi Abe,*a   Takahito Ohshiro,b   Yuko Nakashima,a   Mizuo Maedab  and  Yoshihiro Ito*a  

* Corresponding authors

a Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi Saitama 351-0198, Japan
E-mail: h-abe@riken.jp, y-ito@riken.jp
Fax: +81 (0)48-467-9300
Tel: +81 (0)48-467-9303

b Bioengineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi Saitama 351-0198, Japan

Abstract

Small circular double-stranded RNAs (dsRNAs) were synthesized. The structural analysis by atomic force microscopy gave direct images for the interpretation of the structural strain present in circular dsRNAs. Finally, we demonstrated that circular dsRNA caused RNAi effect in cells.

Graphical abstract: Synthesis and characterization of small circular double-stranded RNAs

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Article information

DOI
https://doi.org/10.1039/C0CC04551A
Article type
Communication
Submitted
22 Oct 2010
Accepted
01 Dec 2010
First published
21 Dec 2010

Chem. Commun., 2011,47, 2125-2127

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Synthesis and characterization of small circular double-stranded RNAs

N. Abe, H. Abe, T. Ohshiro, Y. Nakashima, M. Maeda and Y. Ito, Chem. Commun., 2011, 47, 2125 DOI: 10.1039/C0CC04551A

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