Issue 12, 2011
From the journal:

Chemical Communications

The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction†

Chaofeng Dai,a   Lifang Wang,a   Jia Sheng,a   Hanjing Peng,a   Alexander Boryanov Draganov,a   Zhen Huanga  and  Binghe Wang*a  

* Corresponding authors

a Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30302-4098, USA
E-mail: wang@gsu.edu
Fax: +1 4044135543
Tel: +1 4044135545

Abstract

The first chemical incorporation of the boronic acid group into DNA using a copper-free click reagent was reported. Compared with the PCR-based method, this approach allows for site-specific incorporation and synthesis on a larger scale.

Graphical abstract: The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction

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Article information

DOI
https://doi.org/10.1039/C0CC04546B
Article type
Communication
Submitted
21 Oct 2010
Accepted
17 Jan 2011
First published
08 Feb 2011

Chem. Commun., 2011,47, 3598-3600

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The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction

C. Dai, L. Wang, J. Sheng, H. Peng, A. B. Draganov, Z. Huang and B. Wang, Chem. Commun., 2011, 47, 3598 DOI: 10.1039/C0CC04546B

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