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Issue 9, 2011
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Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

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Abstract

An efficient, safe and scalable procedure for the continuous flow thermolysis of azidoacrylates to yield indoles has been developed and was applied to the synthesis of related heterocycles. The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid.

Graphical abstract: Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

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Article information


Submitted
18 Oct 2010
Accepted
01 Dec 2010
First published
20 Dec 2010

Chem. Commun., 2011,47, 2688-2690
Article type
Communication

Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

A. G. O'Brien, F. Lévesque and P. H. Seeberger, Chem. Commun., 2011, 47, 2688
DOI: 10.1039/C0CC04481D

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