Issue 4, 2011
From the journal:

Chemical Communications

Synthetic oligodeoxynucleotide purification by polymerization of failure sequences†

Shiyue Fang,*a   Suntara Fueangfung,a   Xi Lin,a   Xiang Zhang,a   Wenpeng Mai,a   Lanrong Bia  and  Sarah A. Greena  

* Corresponding authors

a Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA
E-mail: shifang@mtu.edu
Fax: +1 906-487-2061
Tel: +1 906-487-2023

Abstract

Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramidite followed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drug purification.

Graphical abstract: Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0CC04374E
Article type
Communication
Submitted
12 Oct 2010
Accepted
29 Oct 2010
First published
17 Nov 2010

Chem. Commun., 2011,47, 1345-1347

Permissions

Request permissions

Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

S. Fang, S. Fueangfung, X. Lin, X. Zhang, W. Mai, L. Bi and S. A. Green, Chem. Commun., 2011, 47, 1345 DOI: 10.1039/C0CC04374E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements