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Issue 8, 2011
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An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation

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Abstract

The low reactivity of peptide-prolyl-thioesters in native chemical ligation is not due to steric effects at the β-carbon, but rather to the presence of a carbonyl moiety on the nitrogen atom of the proline.

Graphical abstract: An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation

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Article information


Submitted
28 Sep 2010
Accepted
22 Nov 2010
First published
21 Dec 2010

Chem. Commun., 2011,47, 2342-2344
Article type
Communication

An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation

S. B. Pollock and S. B.H. Kent, Chem. Commun., 2011, 47, 2342
DOI: 10.1039/C0CC04120C

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