Issue 4, 2011
From the journal:

Chemical Communications

Robust electrochemical system for screening single nucleotide polymorphisms†

Rong Hu,a   Zai-Sheng Wu,*a   Songbai Zhang,a   Guo-Li Shen*a  and  Ruqin Yua  

* Corresponding authors

a State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China
E-mail: zswu@hnu.cn; glshen@hnu.cn
Fax: +86 7318821916
Tel: +86 731-8821916

Abstract

A highly sensitive and selective electrochemical DNA signaling scheme, which identifies the point mutation existing in target DNA sequence, is developed based on the combination of label-free hairpin probe (HP)/DNA endonuclease with zirconia (ZrO2) nanoparticle film, representing a promising screening platform for the accurate diagnosis of infections and genetic diseases as well as for environmental and forensic applications.

Graphical abstract: Robust electrochemical system for screening single nucleotide polymorphisms

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Article information

DOI
https://doi.org/10.1039/C0CC03884A
Article type
Communication
Submitted
15 Sep 2010
Accepted
27 Oct 2010
First published
22 Nov 2010

Chem. Commun., 2011,47, 1294-1296

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Robust electrochemical system for screening single nucleotide polymorphisms

R. Hu, Z. Wu, S. Zhang, G. Shen and R. Yu, Chem. Commun., 2011, 47, 1294 DOI: 10.1039/C0CC03884A

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