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Issue 3, 2011
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Ribonuclease S redux

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Abstract

The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic activity. Although this archetypal protein-fragment complementation system has been the object of historic work in protein chemistry, intrinsic limitations compromise its utility. Modern methods are shown to overcome those limitations and enable new applications.

Graphical abstract: Ribonuclease S redux

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Publication details

The article was received on 14 Sep 2010, accepted on 05 Oct 2010 and first published on 16 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC03864D
Chem. Commun., 2011,47, 973-975

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    Ribonuclease S redux

    R. W. Watkins, U. Arnold and R. T. Raines, Chem. Commun., 2011, 47, 973
    DOI: 10.1039/C0CC03864D

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