Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry

Marian Amela-Cortes; Victor Roullier; Cécile Wolpert; Stefanie Neubauer; Horst Kessler; Olivier Bedel; Serge Mignani; Valérie Marchi-Artzner

doi:10.1039/C0CC03753B

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Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry†

Marian Amela-Cortes,^a Victor Roullier,^a Cécile Wolpert,^a Stefanie Neubauer,^b Horst Kessler,^b Olivier Bedel,^c Serge Mignani^c and Valérie Marchi-Artzner*^a

Author affiliations

* Corresponding authors

^a Sciences Chimiques de Rennes, UMR 6226 C.N.R.S., Campus de Beaulieu, Université Rennes 1, Rennes, France
E-mail: valerie.marchi-artzner@univ-rennes1.fr

^b Institute for Advanced Study and Center of Integrated Protein Science at Technische Universität München, Garching, Germany

^c Sanofi-Aventis Recherche et Développement, Centre de Recherche de Vitry-Alforville, 13 Quai Jules Guesde, 94400 Vitry-sur-Seine, France

Abstract

Here we report the synthesis of monofunctional PEGylated amide ligands that were used to prepare bioactivable quantum dots of a 20 nm diameter with a controlled mean number of the covalently grafted ligands. They are stable in aqueous medium of high salinity including a large pH domain.

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Supplementary files

(Fig. S1) Surface pressure curves, (Fig. S2) Electrophoresis Agarose gel images, (Fig. S3) Fluorescence intensity and mean hydrodynamic diameter, (Fig. S4) Colloidal stability versus pH and time, (Fig. S5) Fluorescence Calibration curves. Control experiment (Fig. S7). Data relative to the optimization of the covalent coupling agents: EDC (Fig. S8 a, b). Finally all the experimental methods relative to the synthesis of the ligands and the characterization of the QD are described PDF (507K)

Article information

DOI: https://doi.org/10.1039/C0CC03753B
Article type: Communication
Submitted: 09 Sep 2010
Accepted: 01 Nov 2010
First published: 22 Nov 2010

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Chem. Commun., 2011,47, 1246-1248

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Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry

M. Amela-Cortes, V. Roullier, C. Wolpert, S. Neubauer, H. Kessler, O. Bedel, S. Mignani and V. Marchi-Artzner, Chem. Commun., 2011, 47, 1246 DOI: 10.1039/C0CC03753B

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Chemical Communications

Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry†

Abstract

Supplementary files

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Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry

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