Issue 8, 2011
From the journal:

Chemical Communications

Silver nanocluster aptamers: in situ generation of intrinsically fluorescent recognition ligands for protein detection†

Jaswinder Sharma,a   Hsin-Chih Yeh,a   Hyojong Yoo,‡a   James H. Wernera  and  Jennifer S. Martinez*a  

* Corresponding authors

a MPA-CINT, Mail Stop, K771, Los Alamos National Laboratory, Los Alamos, USA
E-mail: jenm@lanl.gov
Fax: +1 505-665-9030
Tel: +1 505-665-0045

Abstract

We have synthesized an intrinsically fluorescent recognition ligand that combines the high fluorescence quantum yield (>50%) of oligonucleotide templated AgNCs with the specificity and strong binding affinity of DNA aptamers for their target proteins, to develop a new strategy for detection of specific proteins.

Graphical abstract: Silver nanocluster aptamers: in situ generation of intrinsically fluorescent recognition ligands for protein detection

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Article information

DOI
https://doi.org/10.1039/C0CC03711G
Article type
Communication
Submitted
07 Sep 2010
Accepted
16 Nov 2010
First published
09 Dec 2010

Chem. Commun., 2011,47, 2294-2296

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Silver nanocluster aptamers: in situ generation of intrinsically fluorescent recognition ligands for protein detection

J. Sharma, H. Yeh, H. Yoo, J. H. Werner and J. S. Martinez, Chem. Commun., 2011, 47, 2294 DOI: 10.1039/C0CC03711G

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