Probing the role of the bridging C509 between the [Fe4S4] cubane and the [NipNid] centre in the A-cluster of acetyl-coenzyme A synthase

Yi Liu; Xiaofei Zhu; Feng Wang; Tianlei Ying; Pingwei Li; Zhong-Xian Huang; Xiangshi Tan

doi:10.1039/C0CC03587D

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Probing the role of the bridging C509 between the [Fe₄S₄] cubane and the [Ni_pNi_d] centre in the A-cluster of acetyl-coenzyme A synthase†

Yi Liu,^a Xiaofei Zhu,^a Feng Wang,^b Tianlei Ying,^a Pingwei Li,^c Zhong-Xian Huang^a and Xiangshi Tan*^a

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* Corresponding authors

^a Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
E-mail: xstan@fudan.edu.cn
Fax: +86 21-65641740
Tel: +86 21-55664475

^b Department of Chemistry, The Scripts Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

^c Department of Biochemistry & Biophysics, Texas A & M University, College Station, TX 77843, USA

Abstract

The A-cluster of acetyl-coenzyme A synthase consists of an [Fe₄S₄] cubane bridged to a [Ni_pNi_d] centre via C509 cysteinate. The bridging cysteinate, which could be substituted by histidine imidazole, mediates “communication” between the [Fe₄S₄] cubane and the [Ni_pNi_d] centre during the synthesis of acetyl-coenzyme A.

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Article information

DOI: https://doi.org/10.1039/C0CC03587D
Article type: Communication
Submitted: 31 Aug 2010
Accepted: 21 Oct 2010
First published: 22 Nov 2010

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Chem. Commun., 2011,47, 1291-1293

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Probing the role of the bridging C509 between the [Fe₄S₄] cubane and the [Ni_pNi_d] centre in the A-cluster of acetyl-coenzyme A synthase

Y. Liu, X. Zhu, F. Wang, T. Ying, P. Li, Z. Huang and X. Tan, Chem. Commun., 2011, 47, 1291 DOI: 10.1039/C0CC03587D

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