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Issue 3, 2011
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Preparation of benzolactams by Pd(ii)-catalyzed carbonylation of N-unprotected arylethylamines

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Abstract

An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α-amino esters to yield 6-membered benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process.

Graphical abstract: Preparation of benzolactams by Pd(ii)-catalyzed carbonylation of N-unprotected arylethylamines

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Publication details

The article was received on 25 Aug 2010, accepted on 21 Oct 2010 and first published on 15 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC03478A
Chem. Commun., 2011,47, 1054-1056

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    Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines

    B. López, A. Rodriguez, D. Santos, J. Albert, X. Ariza, J. Garcia and J. Granell, Chem. Commun., 2011, 47, 1054
    DOI: 10.1039/C0CC03478A

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