Issue 1, 2011
From the journal:

Chemical Communications

Stability of small mesoporous silicananoparticles in biological media†‡

Yu-Shen Lin,a   Nardine Abadeera  and  Christy L. Haynes*a  

* Corresponding authors

a Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, USA
E-mail: chaynes@umn.edu
Web: http://www.chem.umn.edu/groups/haynes
Fax: +1 612-626-7541
Tel: +1 612-626-1096

Abstract

In this work, sub-50 nm pegylated mesoporous silica nanoparticles prepared with hydrothermal treatment are shown to have long-term stability in various media at both room and physiological temperature. Compared to bare mesoporous silica nanoparticles, the highly pegylated mesoporous silica nanoparticles show significantly improved biocompatibility and decreased macrophage uptake, making these nanoparticles viable for in vivo stealth drug delivery applications.

Graphical abstract: Stability of small mesoporous silica nanoparticles in biological media

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Article information

DOI
https://doi.org/10.1039/C0CC02923H
Article type
Communication
Submitted
30 Jul 2010
Accepted
08 Oct 2010
First published
16 Nov 2010

Chem. Commun., 2011,47, 532-534

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Stability of small mesoporous silica nanoparticles in biological media

Y. Lin, N. Abadeer and C. L. Haynes, Chem. Commun., 2011, 47, 532 DOI: 10.1039/C0CC02923H

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