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Issue 2, 2011
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A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases†‡

Jennifer Hopwood,a   Matthew D. Truppo,a   Nicholas J. Turner*a  and  Richard C. Lloydb  
Author affiliations

* Corresponding authors

a School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester M17DN, UK
E-mail: Nicholas.turner@manchester.ac.uk
Fax: +44 (0)161 306 5173

b Dr Reddy's, Chirotech Technology Ltd, Unit 162, Cambridge Science Park, Milton Road, Cambridge CB4 0GH, UK
E-mail: rlloyd@drreddys.com
Fax: +44 (0)1223 506701
Tel: +44 (0)1223 728010

Abstract

A fast and sensitive method for screening transaminase activity and enantioselectivity, using D- and L-amino acid oxidases, allows new amine substrates to be rapidly identified.

Graphical abstract: A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

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Publication details

The article was received on 30 Jul 2010, accepted on 19 Oct 2010 and first published on 11 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC02919J
Chem. Commun., 2011,47, 773-775

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    A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

    J. Hopwood, M. D. Truppo, N. J. Turner and R. C. Lloyd, Chem. Commun., 2011, 47, 773
    DOI: 10.1039/C0CC02919J

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