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Issue 11, 2011
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Molecular imaging and depth profiling by mass spectrometrySIMS, MALDI or DESI?

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Abstract

The possibility of exploiting the analytical power of mass spectrometry to image the chemistry of biological and similarly complex materials without the use of tags and with good spatial resolution is seductive. The status, strengths, weaknesses and complementarity of the three main techniques are briefly reviewed and assessed.

Graphical abstract: Molecular imaging and depth profiling by mass spectrometry—SIMS, MALDI or DESI?

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Publication details

The article was received on 04 Jan 2011, accepted on 23 Feb 2011 and first published on 04 Apr 2011


Article type: Critical Review
DOI: 10.1039/C1AN00008J
Analyst, 2011,136, 2199-2217

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    Molecular imaging and depth profiling by mass spectrometrySIMS, MALDI or DESI?

    J. C. Vickerman, Analyst, 2011, 136, 2199
    DOI: 10.1039/C1AN00008J

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