Issue 1, 2011

A naked-eye visible and fluorescence “turn-on” probe for acetyl-cholinesterase assay and thiols as well as imaging of living cells

Abstract

A resorufin derivative with a DBS group (probe 1) was designed and investigated for the detection of acetylcholinesterase (AChE) and inhibitor screening. The new assay is based on cascade enzymatic and chemical reactions of ATC, AChE and probe 1, and it can be carried out in a dual-signal detection mode. Moreover, the results show that probe 1 can be used for cell fluorescence staining.

Graphical abstract: A naked-eye visible and fluorescence “turn-on” probe for acetyl-cholinesterase assay and thiols as well as imaging of living cells

Supplementary files

Article information

Article type
Paper
Submitted
29 Jun 2010
Accepted
23 Aug 2010
First published
06 Oct 2010

Analyst, 2011,136, 191-195

A naked-eye visible and fluorescence “turn-on” probe for acetyl-cholinesterase assay and thiols as well as imaging of living cells

K. Cui, Z. Chen, Z. Wang, G. Zhang and D. Zhang, Analyst, 2011, 136, 191 DOI: 10.1039/C0AN00456A

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