Issue 22, 2011
From the journal:

Soft Matter

Cubosomes for ruthenium complex delivery: formulation and characterization†

Gaetano Mangiapia,a   Mauro Vaccaro,b   Gerardino D'Errico,a   Henrich Frielinghaus,c   Aurel Radulescu,c   Vitaliy Pipich,c   Anna M. Carnerupd  and  Luigi Paduano*a  

* Corresponding authors

a Department of Chemistry, University of Naples “Federico II”, Via Cinthia, Naples, Italy
E-mail: luigi.paduano@unina.it
Fax: +390 81 674090
Tel: +390 81 674250

b Procter and Gamble UK Cobalt 3, Silver Fox Way Cobalt Business Park, Newcastle upon Tyne, UK

c Jülich Centre for Neutron Science, Lichtenbergstrasse 1, Garching, Germany

d Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, Lund, Sweden

Abstract

An amphiphilic ruthenium-based molecule (DOPURu) with potential antineoplastic activity has been synthesized, and its aggregation behavior in the presence of phospholipids has been investigated. A very rich variety of aggregates has been found, spanning from vesicles to cubic bicontinuous phases. Cubosomes here presented represent one of the first systems with potential use for medical therapy.

Graphical abstract: Cubosomes for ruthenium complex delivery: formulation and characterization

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Article information

DOI
https://doi.org/10.1039/C1SM06323E
Article type
Communication
Submitted
13 Jul 2011
Accepted
12 Sep 2011
First published
03 Oct 2011

Soft Matter, 2011,7, 10577-10580

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Cubosomes for ruthenium complex delivery: formulation and characterization

G. Mangiapia, M. Vaccaro, G. D'Errico, H. Frielinghaus, A. Radulescu, V. Pipich, A. M. Carnerup and L. Paduano, Soft Matter, 2011, 7, 10577 DOI: 10.1039/C1SM06323E

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