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Issue 20, 2011
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Calcium-ion-controlled nanoparticle-induced tubulation in supported flat phospholipid vesicles

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Abstract

Biological nanotubes, often referred to as tunneling nanotubes, fulfill important functions within the cell, e.g. by supplying cell components, conducting signals and transporting virus particles and bacteria. Many functions are still insufficiently understood, which has placed these nanostructures in the focus of recent investigation. We report here on our observations of transient tubulation in nanoparticle-containing, supported flat giant unilamellar vesicles (FGUVs). The encapsulation of nanoparticles in FGUVs in conjunction with low (1–4 mM) Ca2+ in the ambient buffer solution resulted in transient tube formation. Tubes extended from the FGUV up to a length of several hundred micrometres and exhibited, on some occasions, vesicle encapsulation. The findings represent an interesting confirmation of several reported theoretical and practical models of tube formation in biological or biomimetic systems.

Graphical abstract: Calcium-ion-controlled nanoparticle-induced tubulation in supported flat phospholipid vesicles

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Supplementary files

Article information


Submitted
15 Apr 2011
Accepted
16 Aug 2011
First published
16 Sep 2011

Soft Matter, 2011,7, 9706-9713
Article type
Paper

Calcium-ion-controlled nanoparticle-induced tubulation in supported flat phospholipid vesicles

I. Gözen, C. Billerit, P. Dommersnes, A. Jesorka and O. Orwar, Soft Matter, 2011, 7, 9706
DOI: 10.1039/C1SM05677H

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