Jump to main content
Jump to site search

Issue 18, 2011
Previous Article Next Article

Self-assembled liposomes from amphiphilic electrospun nanofibers

Author affiliations

Abstract

Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1–33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.

Graphical abstract: Self-assembled liposomes from amphiphilic electrospun nanofibers

Back to tab navigation

Article information


Submitted
24 May 2011
Accepted
29 Jun 2011
First published
03 Aug 2011

Soft Matter, 2011,7, 8239-8247
Article type
Paper

Self-assembled liposomes from amphiphilic electrospun nanofibers

D. Yu, C. Branford-White, G. R. Williams, S. W. A. Bligh, K. White, L. Zhu and N. P. Chatterton, Soft Matter, 2011, 7, 8239
DOI: 10.1039/C1SM05961K

Social activity

Search articles by author

Spotlight

Advertisements