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Issue 20, 2011
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Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

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Abstract

Controlling a coil-to-helix transition in peptidepolymer conjugates with soft stimuli requires the careful balancing of stabilizing and destabilizing effects in the peptide segment. The transition between two secondary structures of a bioconjugate is realized using calcium ions to establish a biomimetic control mechanism. Regulation of Ca2+-ion levels via competitive Ca2+-ion binders made the process reversible.

Graphical abstract: Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

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Article information


Submitted
08 Apr 2011
Accepted
24 May 2011
First published
09 Jun 2011

Soft Matter, 2011,7, 9616-9619
Article type
Communication

Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

R. I. Kühnle, D. Gebauer and H. G. Börner, Soft Matter, 2011, 7, 9616
DOI: 10.1039/C1SM05625E

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