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Issue 5, 2011
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Permeability control in stimulus-responsive colloidosomes

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Abstract

Self-assembly of colloidal particles in the liquid interface of double emulsion droplets can be used to fabricate “colloidosome” microcapsules, which have great potential as vehicles for the controlled delivery of drugs or other cargoes. Here we present a novel class of aqueous core colloidosomes that combine the benefit of low capsule permeability (good cargo retention) with the option of a stimulus-triggered fast release in a target environment. Complete or partial dissolution of the capsule walls in response to a mild pH change is achieved in each case through the use of responsive particles made from polymers with pH-switchable solubility. We demonstrate three methods of controlling the capsule permeability prior to release while maintaining the intended response to the release trigger.

Graphical abstract: Permeability control in stimulus-responsive colloidosomes

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Article information


Submitted
06 Oct 2010
Accepted
19 Nov 2010
First published
22 Dec 2010

Soft Matter, 2011,7, 1948-1956
Article type
Paper

Permeability control in stimulus-responsive colloidosomes

A. San Miguel and S. H. Behrens, Soft Matter, 2011, 7, 1948
DOI: 10.1039/C0SM01107J

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