Issue 8, 2011
From the journal:

Chemical Science

Catalytic enantioselective assembly of complex molecules containing embedded quaternary stereogenic centres from simple anisidine derivatives†

Rafael Leon,a   Anup Jawalekar,a   Thomas Rederta  and  Matthew J. Gaunt*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, United Kingdom
E-mail: mjg32@cam.ac.uk
Tel: +0044 1223 336318

Abstract

Here we report an electrophile-triggered, secondary amine-catalyzed, enantioselective dearomatisation process that converts simple planar anisidine derivatives into complex tricyclic structures containing a quaternary stereogenic centre embedded within a densely functionalised molecule.

Graphical abstract: Catalytic enantioselective assembly of complex molecules containing embedded quaternary stereogenic centres from simple anisidine derivatives

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Article information

DOI
https://doi.org/10.1039/C1SC00218J
Article type
Edge Article
Submitted
05 Apr 2011
Accepted
28 Apr 2011
First published
18 May 2011

Chem. Sci., 2011,2, 1487-1490

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Catalytic enantioselective assembly of complex molecules containing embedded quaternary stereogenic centres from simple anisidine derivatives

R. Leon, A. Jawalekar, T. Redert and M. J. Gaunt, Chem. Sci., 2011, 2, 1487 DOI: 10.1039/C1SC00218J

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