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Issue 7, 2011

Photosensitised pyrimidine dimerisation in DNA

Author affiliations

Abstract

Triplet-mediated pyrimidine (Pyr) dimerisation is a key process in photochemical damage to DNA. It may occur in the presence of a photosensitiser, provided that a number of requirements are fulfilled, such as favourable intersystem crossing quantum yield and high triplet energy. The attention has been mainly focused on cyclobutane pyrimidine dimers, as they are by far the most relevant Pyr photoproducts obtained by sensitisation. The present perspective deals with the involved chemistry, not only in DNA but also in its simple building blocks. It also includes the photophysical characterisation of the Pyr triplet excited states, as well as a brief discussion of the theoretical aspects.

Graphical abstract: Photosensitised pyrimidine dimerisation in DNA

Article information


Submitted
11 Feb 2011
Accepted
29 Mar 2011
First published
04 May 2011

Chem. Sci., 2011,2, 1219-1232
Article type
Perspective

Photosensitised pyrimidine dimerisation in DNA

M. C. Cuquerella, V. Lhiaubet-Vallet, F. Bosca and M. A. Miranda, Chem. Sci., 2011, 2, 1219 DOI: 10.1039/C1SC00088H

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