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Issue 5, 2011
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Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

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Abstract

Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.

Graphical abstract: Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

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Publication details

The article was received on 28 Jun 2011, accepted on 10 Aug 2011 and first published on 07 Sep 2011


Article type: Communication
DOI: 10.1039/C1RA00377A
RSC Adv., 2011,1, 758-760

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    Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

    A. Nagaki, K. Imai, H. Kim and J. Yoshida, RSC Adv., 2011, 1, 758
    DOI: 10.1039/C1RA00377A

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