Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide

Yoshihiro Sasaki; Yuji Tsuchido; Shin-ichi Sawada; Kazunari Akiyoshi

doi:10.1039/C1PY00100K

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Construction of protein-crosslinked nanogels with vitamin B₆ bearing polysaccharide†

Yoshihiro Sasaki,^ab Yuji Tsuchido,^a Shin-ichi Sawada^a and Kazunari Akiyoshi*^ac

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* Corresponding authors

^a Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, Japan
Fax: +81-3-5280-8027
Tel: +81-3-5280-8026

^b PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, Japan

^c Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, Japan
E-mail: akiyoshi@bio.polym.kyoto-u.ac.jp
Fax: +81-75-383-2589
Tel: +81-75-383-2590

Abstract

Protein-crosslinked nanogels were prepared by introducing vitamin B₆ (pyridoxal) to hydrophilic polysaccharide. The pH dependence of Schiff base formation was utilized to generate a pH-sensitive nanogel system. This approach represents a new method to prepare hybrid nanogels crosslinked with biomolecules.

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Article information

DOI: https://doi.org/10.1039/C1PY00100K
Article type: Communication
Submitted: 05 Mar 2011
Accepted: 07 Apr 2011
First published: 28 Apr 2011

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Polym. Chem., 2011,2, 1267-1270

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Construction of protein-crosslinked nanogels with vitamin B₆ bearing polysaccharide

Y. Sasaki, Y. Tsuchido, S. Sawada and K. Akiyoshi, Polym. Chem., 2011, 2, 1267 DOI: 10.1039/C1PY00100K

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