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Issue 2, 2011
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Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

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Abstract

Reversible addition–fragmentation chain transfer (RAFT) of N-isopropylacrylamide with a chain transfer agent containing an activated-ester moiety was employed to prepare well-defined temperature-responsive polymers for conjugation to amine-containing proteins. Bioconjugation efficiency of the polymers with lysozyme was investigated as a function of stoichiometry, polymer molecular weight, and reaction pH. The resulting polymerprotein conjugates retained the temperature-responsive nature of the original polymers.

Graphical abstract: Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

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Article information


Submitted
10 Jun 2010
Accepted
06 Jul 2010
First published
31 Aug 2010

Polym. Chem., 2011,2, 323-327
Article type
Paper

Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

H. Li, A. P. Bapat, M. Li and B. S. Sumerlin, Polym. Chem., 2011, 2, 323
DOI: 10.1039/C0PY00178C

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