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Issue 2, 2011
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Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

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We demonstrate a strategy for producing polymer bioconjugates which display both enzymatic and thermal responsiveness. This is achieved by combining the thermo-responsive properties of poly(2-isopropyl-2-oxazoline) (PiPrOx) with the self-assembly properties of fluorenylmethoxycarbonyl-tyrosine (Fmoc-Y), controlled by a phosphatase triggered mechanism.

Graphical abstract: Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

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Article information

07 Sep 2010
20 Oct 2010
First published
12 Nov 2010

Polym. Chem., 2011,2, 306-308
Article type

Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

P. Caponi, X. Qiu, F. Vilela, F. M. Winnik and R. V. Ulijn, Polym. Chem., 2011, 2, 306
DOI: 10.1039/C0PY00291G

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