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Issue 8, 2011
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Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2

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Abstract

The transient species formed following excitation of fac-[Re(CO)3(F2dppz)(py)]+ (F2dppz = 11,12-difluorodipyrido[3,2-a:2′,3′-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)]2 or [poly(dG-dC)]2 have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900–2100 and 1500–1750 cm−1 respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)]2 complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.

Graphical abstract: Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2

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Publication details

The article was received on 31 Jan 2011, accepted on 14 Apr 2011 and first published on 23 Jun 2011


Article type: Paper
DOI: 10.1039/C1PP05050H
Photochem. Photobiol. Sci., 2011,10, 1355-1364

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    Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2

    Q. Cao, C. M. Creely, E. S. Davies, J. Dyer, T. L. Easun, D. C. Grills, D. A. McGovern, J. McMaster, J. Pitchford, J. A. Smith, X. Sun, J. M. Kelly and M. W. George, Photochem. Photobiol. Sci., 2011, 10, 1355
    DOI: 10.1039/C1PP05050H

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