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Issue 5, 2011
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Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients

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Abstract

We report our preliminary results of a pilot clinical trial of late-stage breast cancer patients treated by laser immunotherapy (LIT), a local intervention using an 805 nm laser for non-invasive irradiation, indocyanine green for selective thermal effect, and immunoadjuvant (glycated chitosan) for immunological stimulation. Ten breast cancer patients were enrolled in this study; all patients were considered to be out of other available treatment options. Toxicity was individually evaluated through physical exams and laboratory tests. Adverse reactions only occurred in the area of treatment due to photothermal injury and local administration of immunoadjuvant. No grade 3 or 4 side effects were observed. Treatment efficacy of LIT was also evaluated by physical examination and tomography. In 8 patients available for evaluation, the objective response rate was 62.5% and the clinical beneficial response rate was 75%. While the study is still ongoing, the initial outcomes of this clinical trial show that LIT is well tolerated and is promising in the treatment of metastatic breast cancer.

Graphical abstract: Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients

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Publication details

The article was received on 14 Oct 2010, accepted on 11 Feb 2011 and first published on 04 Mar 2011


Article type: Paper
DOI: 10.1039/C0PP00306A
Photochem. Photobiol. Sci., 2011,10, 817-821

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    Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients

    X. Li, G. L. Ferrel, M. C. Guerra, T. Hode, J. A. Lunn, O. Adalsteinsson, R. E. Nordquist, H. Liu and W. R. Chen, Photochem. Photobiol. Sci., 2011, 10, 817
    DOI: 10.1039/C0PP00306A

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