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Issue 21, 2011
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Perfluoroalkylation in flow microreactors: generation of perfluoroalkyllithiums in the presence and absence of electrophiles

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Abstract

Perfluoroalkyllithiums were effectively generated from perfluoroalkyl halides in the presence and absence of electrophiles using flow microreactor systems. The in situ trapping with electrophile is conducted at much higher temperatures than those required for batch macro reactors. The subsequent trapping method is quite effective for highly reactive electrophiles that are not compatible with the lithiation process.

Graphical abstract: Perfluoroalkylation in flow microreactors: generation of perfluoroalkyllithiums in the presence and absence of electrophiles

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Publication details

The article was received on 16 Jun 2011, accepted on 16 Aug 2011 and first published on 22 Sep 2011


Article type: Paper
DOI: 10.1039/C1OB06350B
Org. Biomol. Chem., 2011,9, 7559-7563

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    Perfluoroalkylation in flow microreactors: generation of perfluoroalkyllithiums in the presence and absence of electrophiles

    A. Nagaki, S. Tokuoka, S. Yamada, Y. Tomida, K. Oshiro, H. Amii and J. Yoshida, Org. Biomol. Chem., 2011, 9, 7559
    DOI: 10.1039/C1OB06350B

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