Jump to main content
Jump to site search

Issue 23, 2011
Previous Article Next Article

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Author affiliations

Abstract

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used.

Graphical abstract: Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Back to tab navigation

Supplementary files

Article information


Submitted
25 Jul 2011
Accepted
30 Aug 2011
First published
31 Aug 2011

Org. Biomol. Chem., 2011,9, 8171-8177
Article type
Paper

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

L. Muñoz, A. M. Rodriguez, G. Rosell, M. P. Bosch and A. Guerrero, Org. Biomol. Chem., 2011, 9, 8171 DOI: 10.1039/C1OB06251D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements