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Issue 20, 2011
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Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues

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Abstract

Herein we report a parallel solid-phase synthesis of 1,3,5-triazine based nucleoside analogues by a three-step substitution, starting from 2,4,6-trichloro-1,3,5-triazine. A library of 80 galactosyl-1,3,5-triazine compounds was prepared in high purity without extensive reaction conditions or tedious purification, suggesting the generality of this method.

Graphical abstract: Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues

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Supplementary files

Article information


Submitted
10 May 2011
Accepted
26 Jul 2011
First published
27 Jul 2011

Org. Biomol. Chem., 2011,9, 6924-6926
Article type
Communication

Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues

S. Wang, W. S. Lee, H. Ha and Y. Chang, Org. Biomol. Chem., 2011, 9, 6924
DOI: 10.1039/C1OB05733B

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