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Issue 16, 2011
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Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

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Abstract

DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (LeX). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.

Graphical abstract: Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

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Supplementary files

Article information


Submitted
11 Apr 2011
Accepted
20 May 2011
First published
20 May 2011

Org. Biomol. Chem., 2011,9, 5778-5786
Article type
Paper

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

M. Andreini, D. Doknic, I. Sutkeviciute, J. J. Reina, J. Duan, E. Chabrol, M. Thepaut, E. Moroni, F. Doro, L. Belvisi, J. Weiser, J. Rojo, F. Fieschi and A. Bernardi, Org. Biomol. Chem., 2011, 9, 5778
DOI: 10.1039/C1OB05573A

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