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Issue 12, 2011
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Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any additives

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Abstract

The asymmetric alkynylation of aliphatic and aromatic aldehydes with propiolates was mediated by dialkylzinc and a novel prolinol catalyst without high reagent loading and any additives, such as Ti(Oi-Pr)4, to give the corresponding γ-hydroxy-α,β-acetylenic esters with high enantiomeric excess of up to 95%.

Graphical abstract: Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any additives

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The article was received on 29 Mar 2011, accepted on 20 Apr 2011 and first published on 21 Apr 2011


Article type: Communication
DOI: 10.1039/C1OB05489A
Org. Biomol. Chem., 2011,9, 4425-4428

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    Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any additives

    N. Kojima, S. Nishijima, K. Tsuge and T. Tanaka, Org. Biomol. Chem., 2011, 9, 4425
    DOI: 10.1039/C1OB05489A

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