Issue 11, 2011
From the journal:

Organic & Biomolecular Chemistry

A family of multicyclic indolosesquiterpenes from a bacterial endophyte†

Ling Ding,a   Armin Maier,b   Heinz-Herbert Fiebig,b   Wen-Han Linc  and  Christian Hertweck*ad  

* Corresponding authors

a Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, Jena, Germany
E-mail: Christian.Hertweck@hki-jena.de
Fax: + 49 3641 5320804
Tel: + 49 3641 5321100

b Oncotest GmbH, Am Flughafen 12-14, Freiburg, Germany

c State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China

d Chair for Natural Product Chemistry, Friedrich Schiller University, Jena, Germany

Abstract

Three novel indolosesquiterpenes, xiamycin B (1b), indosespene (2), and sespenine (3), along with the known xiamycin A (1a) were isolated from the culture broth of Streptomyces sp. HKI0595, a bacterial endophyte of the widespread mangrove tree Kandelia candel. Agar diffusion assays revealed moderate to strong antimicrobial activities against several bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, while no cytotoxicity against human tumor cell lines was observed. Together with the previously reported oridamycin, the endophyte metabolites represent the first indolosesquiterpenes isolated from prokaryotes.

Graphical abstract: A family of multicyclic indolosesquiterpenes from a bacterial endophyte

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Article information

DOI
https://doi.org/10.1039/C1OB05283G
Article type
Communication
Submitted
21 Feb 2011
Accepted
11 Apr 2011
First published
11 Apr 2011

Org. Biomol. Chem., 2011,9, 4029-4031

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A family of multicyclic indolosesquiterpenes from a bacterial endophyte

L. Ding, A. Maier, H. Fiebig, W. Lin and C. Hertweck, Org. Biomol. Chem., 2011, 9, 4029 DOI: 10.1039/C1OB05283G

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