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Issue 5, 2011
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A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates

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Abstract

α-Isocyanoacetamides, acyl chlorides and dialkylacetylenedicarboxylates undergo a smooth multicomponent reaction to produce dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates in good yield. The scope and mechanism of this new multicomponent transformation are discussed.

Graphical abstract: A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates

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Supplementary files

Article information


Submitted
03 Nov 2010
Accepted
14 Dec 2010
First published
15 Dec 2010

Org. Biomol. Chem., 2011,9, 1627-1631
Article type
Paper

A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates

R. Mossetti, D. Caprioglio, G. Colombano, G. C. Tron and T. Pirali, Org. Biomol. Chem., 2011, 9, 1627
DOI: 10.1039/C0OB00979B

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